Akoss Ofori-Mensah received her BA Honours Degree in English from the University of Ghana. She taught English at Aburi Girls Secondary School for two years and then went to Nottingham University in the UK for a Post Graduate Diploma in English. In 1974, she received an internship at the United Nations Fund For Population Activities in New York for six months and then went on to study a Master’s Degree in Population Education at the University of Chicago, IL.
She returned to Ghana in 1976 and worked with Afram Publications as a Managing Editor. She left Afram in 1978 and joined the Halko Group of Companies, where she rose to become the Managing Director of the Group.
In 1993, Akoss started her own publishing house – Sub-Saharan Publishers for children’s books. Akoss has served on the Ghana Book Publishers Association as the Honorary Secretary and Vice President. She was elected President of the Association from 2003-2005. She has been a member of The African Publishers Network (APNET) and is part of African Books Collective's council of management.