A frontline guide tailored for Over-the-Counter Medicines Sellers (OTCMS), blending regulation, safe dispensing, and community health practice. This handbook serves as both a training and reference resource, aligned with Acts 851 and 857 and the Pharmacy Council operational standards. It provides clear guidance on the scope of practice, permitted versus restricted medicines, record-keeping, ethical conduct, and inspection readiness. The clinical modules cover conditions commonly managed by OTCMS, including malaria, pain and fever, cough and cold, diarrhoea and vomiting, GI complaints, worm infestation, simple skin infections, wound care, and infection prevention. Each chapter features learning outcomes, red-flag checklists, referral flowcharts, dosage guidance, and counselling tips for community settings. Case studies with marking schemes support ongoing competence and professional growth. With its practical tone, visuals, and Ghana-specific relevance, this book empowers OTCMS practitioners to deliver safer, evidence-informed care while enhancing their contribution to national public health goals.